In vitro susceptibility of Haemophilus influenzae to cefixime | Zendy

M. Powell | Zendy; John D. Williams | Zendy

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In vitro susceptibility of Haemophilus influenzae to cefixime

Author(s) -

M. Powell,

John D. Williams

Publication year - 1987

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.31.11.1841

Subject(s) - cefixime , haemophilus influenzae , ampicillin , microbiology and biotechnology , haemophilus , in vitro , cephalosporin , biology , medicine , antibiotics , bacteria , genetics

The in vitro activity of cefixime against 2,458 clinical isolates of Haemophilus influenzae was determined. All the strains were inhibited by less than or equal to 2 micrograms of cefixime per ml, and the modal MIC was 0.03 micrograms/ml. Activity was unaffected by the presence of beta-lactamase produced by 157 isolates. Nineteen of the twenty-four isolates for which cefixime MICs were greater than or equal to 0.5 micrograms/ml were beta-lactamase negative but showed reduced susceptibility to ampicillin.

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