Open AccessPenetration of sulbactam and ampicillin into cerebrospinal fluid of infants and young children with meningitis
Author(s) -
George Foulds,
T. J. Mcbride,
Anthony K. Knirsch,
William J. Rodríguez,
Waheed N. Khan
Publication year - 1987
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.31.11.1703
Subject(s) - sulbactam , ampicillin , meningitis , cerebrospinal fluid , microgram , medicine , anesthesia , gastroenterology , antibiotics , chemistry , microbiology and biotechnology , surgery , biology , biochemistry , antibiotic resistance , imipenem , in vitro
Infusions of 50 mg of sulbactam per kg per day and 400 mg of ampicillin per kg per day in divided doses to infants and children with bacterial meningitis produced levels in cerebrospinal fluid approximately one-third those in serum. Concentrations in cerebrospinal fluid of 5.5 micrograms of sulbactam per ml and 16.0 micrograms of ampicillin per ml declined within a few days of therapy to 1.9 microgram of sulbactam per ml and 5.2 micrograms of ampicillin per ml.