Open AccessFactors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620
Author(s) -
Lisa R. Hirschhorn,
Harold C. Neu
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.30.1.143
Subject(s) - antimicrobial , staphylococcus aureus , microbiology and biotechnology , pseudomonas aeruginosa , in vitro , antibacterial agent , enterobacteriaceae , chemistry , biology , bacteria , antibiotics , escherichia coli , biochemistry , genetics , gene
The in vitro activity of difloxacin (A-56619) and A-56620, two new aryl-difluoroquinolones, was decreased by magnesium at 9 mM and in assay at pH 5.5 or in urine. Resistance was seen with members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus repeatedly exposed to subinhibitory concentrations of the compounds. The frequency of resistance was similar to that found for other new quinolones.