Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit? | Zendy

G. Agnelli | Zendy; A. Del Favero | Zendy; Pasquale Parise | Zendy; Roberto Guerciolini | Zendy; B M Pasticci | Zendy; G.G. Nenci | Zendy; Frederick A. Ofosu | Zendy

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Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit?

Author(s) -

G. Agnelli,

A. Del Favero,

Pasquale Parise,

Roberto Guerciolini,

B M Pasticci,

G.G. Nenci,

Frederick A. Ofosu

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.6.1108

Subject(s) - hypoprothrombinemia , cefamandole , ceftazidime , cephalosporin , latamoxef , ceftriaxone , medicine , cefotaxime , moxalactam , incidence (geometry) , gastroenterology , pharmacology , microbiology and biotechnology , antibiotics , biology , mathematics , vitamin k , bacteria , genetics , pseudomonas aeruginosa , geometry

The reported high incidence of vitamin-K-reversible hypoprothrombinemia associated with the new beta-lactamase-stable cephalosporins prompted us to evaluate the effect on hemostasis of three cephalosporins (cefamandole, ceftriaxone, and ceftazidime) in 30 patients with serious infections. Cefamandole and ceftriaxone, both containing a sulfhydryl group, induced a significant and similar prolongation of prothrombin time and decrease in factor VII activity. Ceftazidime, in contrast, had no effect on these two parameters.

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