Open AccessAztreonam concentration in abdominal tissues and bile
Author(s) -
Roben E. Condon,
Lawrence Friedhoff,
Charles E. Edmiston,
B. Levinson
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.6.1101
Subject(s) - aztreonam , dosing , enterobacteriaceae , medicine , gastroenterology , microbiology and biotechnology , chemistry , biology , antibiotics , escherichia coli , biochemistry , antibiotic resistance , imipenem , gene
Abdominal tissue, serum, and bile samples were obtained from 37 patients given a single, 2-g intravenous infusion of aztreonam immediately prior to an elective abdominal operation. Samples were obtained at 0 to 6 h after dosing. Mean concentrations in tissues and fluids and specimen/serum rations are reported. Levels in tissue and bile exceeded the reported MICs for 90% of most members of the family Enterobacteriaceae for up to 6 h.