Aztreonam concentration in abdominal tissues and bile | Zendy

Roben E. Condon | Zendy; Lawrence Friedhoff | Zendy; Charles E. Edmiston | Zendy; B.L. Levinson | Zendy

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Aztreonam concentration in abdominal tissues and bile

Author(s) -

Roben E. Condon,

Lawrence Friedhoff,

Charles E. Edmiston,

B.L. Levinson

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.6.1101

Subject(s) - aztreonam , dosing , enterobacteriaceae , medicine , gastroenterology , microbiology and biotechnology , chemistry , biology , antibiotics , escherichia coli , biochemistry , antibiotic resistance , imipenem , gene

Abdominal tissue, serum, and bile samples were obtained from 37 patients given a single, 2-g intravenous infusion of aztreonam immediately prior to an elective abdominal operation. Samples were obtained at 0 to 6 h after dosing. Mean concentrations in tissues and fluids and specimen/serum rations are reported. Levels in tissue and bile exceeded the reported MICs for 90% of most members of the family Enterobacteriaceae for up to 6 h.

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