Open AccessLack of relevance of kinetic parameters for exocellular DD-peptidases to cephalosporin MICs
Author(s) -
Donald B. Boyd,
John L. Ott
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.5.774
Subject(s) - cephalosporin , microbiology and biotechnology , gram , strain (injury) , actinomycetales , biology , bacteria , lactam , beta lactam , streptomyces , chemistry , antibiotics , stereochemistry , genetics , anatomy
MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39.