Open AccessComparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits
Author(s) -
John R. Perfect,
D V Savani,
D T Durack
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.4.579
Subject(s) - itraconazole , fluconazole , ketoconazole , cryptococcosis , pharmacokinetics , candida albicans , meningitis , urine , amphotericin b , cerebrospinal fluid , mycosis , pharmacology , medicine , microbiology and biotechnology , cryptococcal meningitis , biology , antifungal , immunology , surgery , human immunodeficiency virus (hiv) , viral disease
Itraconazole and fluconazole, two new triazoles, were examined for their antifungal activity in rabbits. Fluconazole easily crossed the blood-cerebrospinal fluid barrier, and active drug was eliminated in high concentrations in the urine. On the other hand, itraconazole did not cross the blood-cerebrospinal fluid barrier in measurable amounts, and urine concentrations were variable. Despite differences in pharmacokinetics at the site of infection, both agents were equally effective in treating cryptococcal meningitis and candida pyelonephritis in animals. By using a ketoconazole-resistant strain of Candida albicans, we showed that there was cross-resistance in vivo between these two new triazole compounds.