Open AccessDetermination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures
Author(s) -
J. Knöller,
K D Bremm,
W. Schönfeld,
Wolfgang König
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.3.527
Subject(s) - mezlocillin , chromatography , degradation (telecommunications) , high performance liquid chromatography , chemistry , biology , telecommunications , genetics , bacteria , computer science , pseudomonas aeruginosa , piperacillin
A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography. The stability of mezlocillin in serum and buffer was studied at different temperatures (4, -20, -70, and -196 degrees C) over a period of 6 months. Mezlocillin remained stable at -70 and -196 degrees C, whereas degradation was observed at -20 and 4 degrees C in serum and buffer.