Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures | Zendy

J. Knöller | Zendy; K.D. Bremm | Zendy; W. Schönfeld | Zendy; Wolfgang König | Zendy

Open Access

Determination of mezlocillin and its penicilloate and penilloate by high-performance liquid chromatography and stability of mezlocillin at different temperatures

Author(s) -

J. Knöller,

K.D. Bremm,

W. Schönfeld,

Wolfgang König

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.3.527

Subject(s) - mezlocillin , chromatography , degradation (telecommunications) , high performance liquid chromatography , chemistry , biology , telecommunications , genetics , bacteria , computer science , pseudomonas aeruginosa , piperacillin

A method is described for the determination of mezlocillin and its metabolites penicilloic acid and penilloic acid in biological fluids by high-performance liquid chromatography. The stability of mezlocillin in serum and buffer was studied at different temperatures (4, -20, -70, and -196 degrees C) over a period of 6 months. Mezlocillin remained stable at -70 and -196 degrees C, whereas degradation was observed at -20 and 4 degrees C in serum and buffer.

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