Quinolones affect thymidine incorporation into the DNA of human lymphocytes | Zendy

Arne Forsgren | Zendy; A. K. Bergh | Zendy; M Brandt | Zendy; G Hansson | Zendy

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Quinolones affect thymidine incorporation into the DNA of human lymphocytes

Author(s) -

Arne Forsgren,

A. K. Bergh,

M Brandt,

G Hansson

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.3.506

Subject(s) - norfloxacin , thymidine , ofloxacin , quinolone , ciprofloxacin , dna , dna synthesis , antibacterial agent , biology , pharmacology , microbiology and biotechnology , chemistry , antibiotics , biochemistry

The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.

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