Open AccessQuinolones affect thymidine incorporation into the DNA of human lymphocytes
Author(s) -
Arne Forsgren,
A. K. Bergh,
Martha Brandt,
Gertrud Hansson
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.3.506
Subject(s) - norfloxacin , thymidine , ofloxacin , quinolone , ciprofloxacin , dna , dna synthesis , antibacterial agent , biology , pharmacology , microbiology and biotechnology , chemistry , antibiotics , biochemistry
The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.