In vitro inactivation of aminoglycosides by apalcillin | Zendy

D N Wright | Zendy; DeVon C. Hale | Zendy; B J Saxon | Zendy; John M. Matsen | Zendy

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In vitro inactivation of aminoglycosides by apalcillin

Author(s) -

D N Wright,

DeVon C. Hale,

B J Saxon,

John M. Matsen

Publication year - 1986

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.29.2.353

Subject(s) - netilmicin , tobramycin , aminoglycoside , amikacin , gentamicin , sisomicin , incubation , in vitro , chemistry , pharmacology , antibiotics , microbiology and biotechnology , biology , biochemistry

Apalcillin, at concentrations of 75, 150, 300, and 600 micrograms/ml, was combined in vitro with amikacin, gentamicin, netilmicin, or tobramycin. Incubation at 37 degrees C resulted in an apalcillin concentration-dependent and time-dependent decrease of aminoglycoside activity of up to 60%. Amikacin was the most stable and tobramycin was the least stable aminoglycoside under the conditions tested.

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