Open AccessIn vitro inactivation of aminoglycosides by apalcillin
Author(s) -
Donald N. Wright,
DeVon C. Hale,
B J Saxon,
John M. Matsen
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.2.353
Subject(s) - netilmicin , tobramycin , aminoglycoside , amikacin , gentamicin , sisomicin , incubation , in vitro , chemistry , pharmacology , antibiotics , microbiology and biotechnology , biology , biochemistry
Apalcillin, at concentrations of 75, 150, 300, and 600 micrograms/ml, was combined in vitro with amikacin, gentamicin, netilmicin, or tobramycin. Incubation at 37 degrees C resulted in an apalcillin concentration-dependent and time-dependent decrease of aminoglycoside activity of up to 60%. Amikacin was the most stable and tobramycin was the least stable aminoglycoside under the conditions tested.