Open AccessEffect of low-dose dopamine on the pharmacokinetics of tobramycin in dogs
Author(s) -
Mary Kirby,
Joseph F. Dasta,
Deborah K. Armstrong,
Richard D. Tallman
Publication year - 1986
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.29.1.168
Subject(s) - tobramycin , dopamine , crossover study , pharmacokinetics , medicine , placebo , elimination rate constant , anesthesia , pharmacology , antibiotics , chemistry , gentamicin , volume of distribution , biochemistry , alternative medicine , pathology
Low-dose dopamine or a placebo was given to six healthy mongrel dogs, each receiving tobramycin at 2.0 mg/kg on consecutive days in a randomized crossover fashion. Dopamine increased the total and renal clearances and elimination rate constant of tobramycin by 12.5, 20, and 25.9%, respectively, suggesting that low-dose dopamine increases the clearance of tobramycin in dogs primarily through renal mechanisms.