Studies with temocillin in a hamster model of antibiotic-associated colitis | Zendy

Ron Boon | Zendy; A S Beale | Zendy

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Studies with temocillin in a hamster model of antibiotic-associated colitis

Author(s) -

Ron Boon,

A S Beale

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.6.980

Subject(s) - clindamycin , clostridium difficile , antibiotics , cefoxitin , penicillin , colitis , microbiology and biotechnology , hamster , pseudomembranous colitis , medicine , clostridium , pharmacology , biology , bacteria , genetics , staphylococcus aureus

Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin.

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