Open AccessSystemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule
Author(s) -
Elizabeth T. Houang,
A G Lawrence
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.6.964
Subject(s) - liter , ovule , absorption (acoustics) , persistence (discontinuity) , medicine , biology , materials science , geotechnical engineering , engineering , composite material , embryo , microbiology and biotechnology
After vaginal insertion of a 300-mg ovule of tioconazole in 10 patients with vaginal candidiasis, the mean concentration in plasma was 21.2 ng/ml (range, 10.6 to 35.8 ng/ml) at 8 h and was not measurable at 24 h in 9 of 10 patients. The mean vaginal concentration at 24 h was 21.4 mg/liter (range, 2.4 to 50 mg/liter) and remained detectable in 7 of 9 and 2 of 9 patients after 48 and 72 h, respectively.