Open AccessActivity of a peptidyl prodrug, alafosfalin, against anaerobic bacteria
Author(s) -
Sarah F. Grappel,
Albert J. Giovenella,
L. J. NISBET
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.6.961
Subject(s) - clostridium perfringens , microbiology and biotechnology , fusobacterium nucleatum , anaerobic bacteria , prodrug , bacteria , clostridium , antibiotics , bacteroides , fusobacterium , peptostreptococcus , bacteroides fragilis , clostridium difficile , antibacterial agent , peptide , biology , chemistry , biochemistry , genetics , porphyromonas gingivalis
Alafosfalin, an antibacterial phosphonodipeptide requiring peptide transport for activity, was tested for activity against clinical strains of anaerobic bacteria in peptide-free Roche Sensitivity Test Medium no. 5 agar. It was active against Bacteroides spp., Fusobacterium nucleatum, and Clostridium perfringens but not against Clostridium difficile. Alafosfalin activity was antagonized by appropriate peptides. Synergy was obtained with other cell wall-active antibiotics.
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