Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits | Zendy

Françoise Dromer | Zendy; A Contrepois | Zendy; N Brion | Zendy; Christian Klein | Zendy; C Carbon | Zendy

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Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits

Author(s) -

Françoise Dromer,

A Contrepois,

N Brion,

Christian Klein,

C Carbon

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.4.660

Subject(s) - cefsulodin , probenecid , urine , chemistry , urinary system , excretion , medicine , pharmacology , endocrinology , biochemistry , biology , bacteria , ceftazidime , pseudomonas aeruginosa , genetics

The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in alkaline urine (FE = 492 +/- 258%). Renal excretion of cefsulodin alone was not affected by the urinary pH (FE = ca. 100%). In acidic urine, probenecid significantly reduced tubular secretion of cefsulodin (FE = 74 +/- 8%). An inverse pattern was observed in alkaline urine (FE = 122 +/- 18%).

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