Open AccessEffects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits
Author(s) -
Françoise Dromer,
A Contrepois,
N Brion,
Christian Klein,
C Carbon
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.4.660
Subject(s) - cefsulodin , probenecid , urine , chemistry , urinary system , excretion , medicine , pharmacology , endocrinology , biochemistry , biology , bacteria , ceftazidime , pseudomonas aeruginosa , genetics
The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in alkaline urine (FE = 492 +/- 258%). Renal excretion of cefsulodin alone was not affected by the urinary pH (FE = ca. 100%). In acidic urine, probenecid significantly reduced tubular secretion of cefsulodin (FE = 74 +/- 8%). An inverse pattern was observed in alkaline urine (FE = 122 +/- 18%).