Open AccessComparative activity of the quinolones against anaerobic bacteria isolated at community hospitals
Author(s) -
Ellie J. C. Goldstein,
Diane M. Citron
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.4.657
Subject(s) - enoxacin , bacteroides fragilis , norfloxacin , nalidixic acid , anaerobic bacteria , microbiology and biotechnology , clindamycin , fusobacterium , agar dilution , bacteroides , clostridium perfringens , peptostreptococcus , ciprofloxacin , bacteria , antibacterial agent , biology , antibiotics , minimum inhibitory concentration , genetics
The in vitro activity of five quinolone compounds, amoxicillin, and clindamycin against 118 strains of anaerobic bacteria isolated at community hospitals was determined by an agar dilution method. Nalidixic acid and cinoxacin had poor activity, and norfloxacin and enoxacin showed relatively poor activity. Ciprofloxacin was active against Bacteroides fragilis, Fusobacterium species, Clostridium perfringens, and gram-positive cocci. At peak levels achievable in the feces, norfloxacin and enoxacin had moderate activity.