Open AccessAntimicrobial activity of HR810 against 419 strict anaerobic bacteria
Author(s) -
Ronald N. Jones,
E. Gerlach
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.3.413
Subject(s) - cefoxitin , cefotaxime , bacteroides fragilis , antimicrobial , microbiology and biotechnology , anaerobic bacteria , anaerobic exercise , cephalosporin , bacteria , biology , peptostreptococcus , bacteroides , antibiotics , staphylococcus aureus , physiology , genetics
HR810 and four other new beta-lactams were tested against 419 recent clinical anaerobic bacterial isolates. HR810 was found to have an antimicrobial spectrum most similar to that of cefotaxime, inhibiting 52.6% of Bacteroides fragilis group strains and 97.2% of all other anaerobic strains at an MIC of less than or equal to 16 micrograms/ml. Cefoxitin was found to have a narrower antimicrobial spectrum against the gram-positive anaerobic bacteria (8.4 to 10.1% less) than HR810 and cefotaxime, respectively.