Antimicrobial activity of HR810 against 419 strict anaerobic bacteria | Zendy

Ronald N. Jones | Zendy; E. Gerlach | Zendy

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Antimicrobial activity of HR810 against 419 strict anaerobic bacteria

Author(s) -

Ronald N. Jones,

E. Gerlach

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.3.413

Subject(s) - cefoxitin , cefotaxime , bacteroides fragilis , antimicrobial , microbiology and biotechnology , anaerobic bacteria , anaerobic exercise , cephalosporin , bacteria , biology , peptostreptococcus , bacteroides , antibiotics , staphylococcus aureus , physiology , genetics

HR810 and four other new beta-lactams were tested against 419 recent clinical anaerobic bacterial isolates. HR810 was found to have an antimicrobial spectrum most similar to that of cefotaxime, inhibiting 52.6% of Bacteroides fragilis group strains and 97.2% of all other anaerobic strains at an MIC of less than or equal to 16 micrograms/ml. Cefoxitin was found to have a narrower antimicrobial spectrum against the gram-positive anaerobic bacteria (8.4 to 10.1% less) than HR810 and cefotaxime, respectively.

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