Open AccessIn vitro activities of bismuth salts against rotaviruses and other enteric viruses
Author(s) -
Richard L. Ward,
Donna S. Sander,
Douglas R. Knowlton
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.3.306
Subject(s) - echovirus , rotavirus , poliovirus , microbiology and biotechnology , cytotoxicity , in vitro , virology , virus , biology , cytopathic effect , strain (injury) , chemistry , cell culture , virus quantification , enterovirus , biochemistry , genetics , anatomy
Bismuth salts inhibited plaque formation of all enteric viruses tested, which included four strains of rotavirus and one strain each of echovirus, reovirus, and poliovirus. The compounds had no direct virucidal effect at concentrations ranging from 0.025 to 2.5 mg/ml, and the inhibitory effects were observed only at concentrations slightly below those that caused extensive cytotoxicity. Plaque inhibition appeared to result from interference with host cell functions, with secondary inhibition of virus production.