Open AccessPenetration of aztreonam into human bronchial secretions
Author(s) -
Douglas L. Bechard,
Stephen S. Hawkins,
R. Dhruv,
Lawrence Friedhoff
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.2.263
Subject(s) - aztreonam , secretion , medicine , penetration (warfare) , pharmacology , gastroenterology , microbiology and biotechnology , biology , antibiotics , antibiotic resistance , imipenem , operations research , engineering
Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be highest at 4 h. The concentrations in bronchial secretion varied from patient to patient, but each patient had one or more bronchial secretion samples that contained at least 2.7 micrograms of drug per ml.