Penetration of aztreonam into human bronchial secretions | Zendy

Douglas L. Bechard | Zendy; Stephen S. Hawkins | Zendy; R Dhruv | Zendy; Lawrence Friedhoff | Zendy

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Penetration of aztreonam into human bronchial secretions

Author(s) -

Douglas L. Bechard,

Stephen S. Hawkins,

R Dhruv,

Lawrence Friedhoff

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.2.263

Subject(s) - aztreonam , secretion , medicine , penetration (warfare) , pharmacology , gastroenterology , microbiology and biotechnology , biology , antibiotics , antibiotic resistance , imipenem , operations research , engineering

Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be highest at 4 h. The concentrations in bronchial secretion varied from patient to patient, but each patient had one or more bronchial secretion samples that contained at least 2.7 micrograms of drug per ml.

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