Open AccessTherapeutic efficacy of teicoplanin in experimental enterococcal endocarditis
Author(s) -
Paul M. Sullam,
MG Täuber,
C J Hackbarth,
Merle A. Sande
Publication year - 1985
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.27.1.135
Subject(s) - teicoplanin , gentamicin , ampicillin , enterococcus faecalis , endocarditis , antimicrobial , microbiology and biotechnology , medicine , enterococcus , titer , streptococcus , antibiotics , vancomycin , biology , immunology , bacteria , staphylococcus aureus , antibody , genetics
The antimicrobial activities of teicoplanin and ampicillin, alone and in combination with gentamicin, were compared in experimental Streptococcus faecalis endocarditis. Bacterial titers in vegetations of rabbits treated with teicoplanin were significantly lower than those of untreated controls (P less than 0.01) and were equivalent to titers in ampicillin-treated animals. Gentamicin increased the activities of both drugs to a comparable degree.