Positive direct antiglobulin tests due to clavulanic acid | Zendy

Michael E. Williams | Zendy; D Thomas | Zendy; Colleen P. Harman | Zendy; P. D. Mintz | Zendy; Gerald R. Donowitz | Zendy

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Positive direct antiglobulin tests due to clavulanic acid

Author(s) -

Michael E. Williams,

D Thomas,

Colleen P. Harman,

P. D. Mintz,

Gerald R. Donowitz

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.1.125

Subject(s) - clavulanic acid , tobramycin , piperacillin , ticarcillin , hemolysis , hemolytic anemia , chemistry , antibiotics , microbiology and biotechnology , medicine , coombs test , immunology , amoxicillin , antibody , biology , biochemistry , bacteria , gentamicin , pseudomonas aeruginosa , genetics

Clavulanic acid, a beta-lactamase inhibitor, was found to be associated with the development of a positive direct antiglobulin test. Of 23 antibiotic courses in patients treated with ticarcillin, clavulanic acid, and tobramycin, 10 (43.5%) developed positive direct antiglobulin tests versus 2 of 26 (7.7%) patients treated with piperacillin and tobramycin (P = 0.0044). In vitro immunohematological studies showed that clavulanic acid caused a nonimmunologic adsorption of plasma proteins onto the erythrocyte surface. Hemolysis was not associated with such nonimmunologic adsorption. However, the resulting positive antiglobulin test might delay cross matching of blood products for transfusions or interfere with the evaluation of true immune-mediated hemolytic anemia.

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