Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice | Zendy

E B Fraser-Smith | Zendy; Deborah A. Eppstein | Zendy; Y. Vivienne Marsh | Zendy; Thomas R. Matthews | Zendy

Open Access

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice

Author(s) -

E B Fraser-Smith,

Deborah A. Eppstein,

Y. Vivienne Marsh,

Thomas R. Matthews

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.6.937

Subject(s) - herpes simplex virus , alpha interferon , virology , guanine , nucleoside , interferon , recombinant dna , alpha (finance) , interferon alfa , virus , nucleoside analogue , biology , medicine , biochemistry , nucleotide , gene , construct validity , nursing , patient satisfaction

The acyclic nucleoside DHPG [9-(1,3-dihydroxy-2-propoxymethyl)guanine] and recombinant human alpha-interferon of clones A/D potentiate each other's antiviral activity against a systemic infection with herpes simplex virus type 2. The effective dose at which 50% of the mice survived was lowered approximately 10-fold for DHPG when it was given in combination with a marginally effective dose of alpha-interferon and greater than 10-fold for alpha-interferon when it was given in combination with a nontherapeutic dose of DHPG.

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