Open AccessCiprofloxacin penetration into extravascular spaces in a rabbit model
Author(s) -
K L Nichol,
Lance R. Peterson,
Claudine E. Fasching,
Dale N. Gerding
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.6.935
Subject(s) - ciprofloxacin , penetration (warfare) , drug , pharmacology , pharmacokinetics , lagomorpha , antimicrobial , chemistry , medicine , antibiotics , biochemistry , engineering , organic chemistry , operations research
Ciprofloxacin penetration into extravascular spaces was studied in a rabbit Visking chamber model. The drug was administered (7 mg/kg) intramuscularly every 4 h for eight doses. Peak and trough drug levels by dose 8 were 1.3 and 0.35 micrograms/ml in serum and 0.61 and 0.50 micrograms/ml in extravascular sites. The ratio of extravascular site to serum free drug area under the drug curve by dose 8 was 91.1%. This potent, new antimicrobial agent appears to distribute freely to extravascular spaces in this animal model.