Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin | Zendy

Josep M. Gatell | Zendy; J G SanMiguel | Zendy; V. Araujo | Zendy; Leonid Zamora | Zendy; J Mañá | Zendy; ML Boquera Ferrer | Zendy; M Bonet | Zendy; M. Bohe | Zendy; M. Teresa Jiménez de Anta | Zendy

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Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin

Author(s) -

Josep M. Gatell,

J G SanMiguel,

V. Araujo,

Leonid Zamora,

J Mañá,

ML Boquera Ferrer,

M Bonet,

M. Bohe,

M. Teresa Jiménez de Anta

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.5.766

Subject(s) - netilmicin , tobramycin , nephrotoxicity , medicine , toxicity , aminoglycoside , gentamicin , prospective cohort study , anesthesia , antibiotics , chemistry , biochemistry

Netilmicin or tobramycin was administered to 197 patients in a prospective randomized double-blind trial. Of these patients, 140 recipients of nine or more doses of netilmicin or tobramycin could be evaluated for nephrotoxicity. Fifty-five patients were able to cooperate in the administration of serial audiograms. Nephrotoxicity of similar severity developed in 7 of 73 (9.6%) recipients of tobramycin and in 7 of 67 (10.4%) recipients of netilmicin (P greater than 0.05). Mild or slight auditory toxicity developed in 5 of 28 (17.8%) recipients of tobramycin and in 2 of 27 (7.4%) recipients of netilmicin (P greater than 0.05).

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