Open AccessProspective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin
Author(s) -
Josep M. Gatell,
J G SanMiguel,
V Araujo,
Leonid Zamora,
Juan Mañá,
ML Boquera Ferrer,
M Bonet,
Måns Bohe,
M. T. Jimenez De Anta
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.5.766
Subject(s) - netilmicin , tobramycin , nephrotoxicity , medicine , toxicity , aminoglycoside , gentamicin , anesthesia , prospective cohort study , antibiotics , biology , microbiology and biotechnology
Netilmicin or tobramycin was administered to 197 patients in a prospective randomized double-blind trial. Of these patients, 140 recipients of nine or more doses of netilmicin or tobramycin could be evaluated for nephrotoxicity. Fifty-five patients were able to cooperate in the administration of serial audiograms. Nephrotoxicity of similar severity developed in 7 of 73 (9.6%) recipients of tobramycin and in 7 of 67 (10.4%) recipients of netilmicin (P greater than 0.05). Mild or slight auditory toxicity developed in 5 of 28 (17.8%) recipients of tobramycin and in 2 of 27 (7.4%) recipients of netilmicin (P greater than 0.05).