Open AccessAntibacterial activities of nitrothiazole against Campylobacter jejuni and Campylobacter coli
Author(s) -
Hof H,
M Rieffert,
V. Sticht-Groh,
O. Zák,
Ernst Schweizer
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.4.498
Subject(s) - nitrofuran , furazolidone , metronidazole , nitrofurazone , campylobacter jejuni , microbiology and biotechnology , niridazole , campylobacter , nitrofurantoin , tinidazole , nitroimidazole , biology , chemistry , antibiotics , medicine , bacteria , traditional medicine , ciprofloxacin , schistosomiasis , organic chemistry , immunology , genetics , helminths
Niridazole (Ambilhar) and three other newly synthesized nitrothiazole derivatives were highly active against 19 microaerophilic campylobacters (minimum concentration required to inhibit 50% of strains [MIC50], 0.0075 to 0.015 mg/liter). There were, however, considerable differences in the susceptibility among strains tested, and one nitrothiazole derivative was rather inactive (MIC50, 2 mg/liter). Nitroimidazole derivatives, such as metronidazole and tinidazole, were less active (MIC50, 2 and 4 mg/liter, respectively). The nitrofuran derivatives, such as nitrofurazone and nitrofurantoin, were also less active (MIC50, 1 mg/liter). Niridazole and another potent nitrothiazole derivative killed the campylobacters rapidly at low concentrations. In contrast, much higher concentrations of metronidazole were required to achieve bactericidal values.