Protection by D-amino acids against growth inhibition and lysis caused by beta-lactam antibiotics | Zendy

Elaine Tuomanen | Zendy; Alexander Tomasz | Zendy

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Protection by D-amino acids against growth inhibition and lysis caused by beta-lactam antibiotics

Author(s) -

Elaine Tuomanen,

Alexander Tomasz

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.3.414

Subject(s) - antibiotics , amino acid , escherichia coli , lysis , chemistry , antibacterial activity , lactam , antibacterial agent , enterobacteriaceae , microbiology and biotechnology , biology , bacteria , biochemistry , stereochemistry , gene , genetics

D-Isomers of several amino acids completely protected growing cultures of Escherichia coli against all antibacterial effects of beta-lactam antibiotics up to approximately two to three times the MICs of the antibiotics. L-Isomers of amino acids were ineffective. Protection depended on the concentration and time of addition of the D-amino acids. This appears to be the first demonstration of natural products capable of reversing the antibacterial effects of beta-lactam antibiotics.

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