Tetracycline diffusion through phospholipid bilayers and binding to phospholipids | Zendy

Manfred Argast | Zendy; C F Beck | Zendy

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Tetracycline diffusion through phospholipid bilayers and binding to phospholipids

Author(s) -

Manfred Argast,

C F Beck

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.2.263

Subject(s) - liposome , tetracycline , phospholipid , lipid bilayer , chemistry , diffusion , biochemistry , biophysics , membrane , biology , antibiotics , physics , thermodynamics

The ability of tetracycline to pass through phospholipid bilayers by diffusion was investigated. Liposomes did not retain enclosed tetracycline. Accumulation of tetracycline was observed with liposomes containing entrapped Tet repressor protein. These results indicate that the drug can pass through lipid bilayers. The antibiotic was also shown to bind to liposomes and isolated phospholipids.

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