Aztreonam concentrations in human prostatic tissue | Zendy

Paul O. Madsen | Zendy; R Dhruv | Zendy; Lawrence Friedhoff | Zendy

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Aztreonam concentrations in human prostatic tissue

Author(s) -

Paul O. Madsen,

R Dhruv,

Lawrence Friedhoff

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.1.20

Subject(s) - aztreonam , prostatitis , microgram , prostate , medicine , urology , intramuscular injection , transurethral resection of the prostate , chemistry , microbiology and biotechnology , antibiotics , biology , biochemistry , in vitro , antibiotic resistance , imipenem , cancer

The concentrations of aztreonam in human prostatic tissue specimens obtained by transurethral resection were measured in nine patients after the intramuscular administration of a single 1-g dose. The average concentration of aztreonam was 7.8 microgram/g of prostate between 50 and 180 min after dosage. The average ratio of the drug concentration in prostate to that in serum was 0.25. The concentrations of aztreonam achieved were significantly higher than the MICs for most members of the family Enterobacteriaceae implicated in chronic prostatitis.

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