Open AccessAntimicrobial spectrum of Win 49375
Author(s) -
Nilda V. Jacobus,
Francis P. Tally,
Michael Barza
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.1.104
Subject(s) - bacteroides fragilis , clostridia , antimicrobial , microbiology and biotechnology , gentamicin , pseudomonas aeruginosa , potency , bacteroides , clindamycin , biology , enterobacteriaceae , antibiotics , chemistry , bacteria , escherichia coli , in vitro , biochemistry , genetics , gene
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375 had moderate activity against clostridia but little against Bacteroides fragilis. The drug showed a marked inoculum effect at 10(8) CFU/ml and a slight decrease in potency at pH 5.