Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase | Zendy

AnnaKarin Larsson | Zendy; PeiZhen Tao | Zendy

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Phosphorylation of four acyclic guanosine analogs by herpes simplex virus type 2 thymidine kinase

Author(s) -

AnnaKarin Larsson,

PeiZhen Tao

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.25.4.524

Subject(s) - thymidine kinase , guanosine , guanine , thymidine , herpes simplex virus , phosphorylation , kinase , biology , nucleotide salvage , enzyme , biochemistry , chemistry , microbiology and biotechnology , virology , nucleotide , virus , dna , gene

Four acyclic guanosine analogs, the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, and acyclovir were compared in enzyme kinetic experiments, using purified herpes simplex virus type 2 thymidine kinase. All four analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by the viral thymidine kinase, but different affinities and relative rates of phosphorylation were observed.

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