Effect of subminimal inhibitory concentrations of antimicrobial agents on the piliation and adherence of Neisseria meningitidis | Zendy

BjørnErik Kristiansen | Zendy; L Rustad | Zendy; Oddvar Spanne | Zendy; Bjarne Bjorvatn | Zendy

Open Access

Effect of subminimal inhibitory concentrations of antimicrobial agents on the piliation and adherence of Neisseria meningitidis

Author(s) -

BjørnErik Kristiansen,

L Rustad,

Oddvar Spanne,

Bjarne Bjorvatn

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.5.731

Subject(s) - lincomycin , neisseria meningitidis , microbiology and biotechnology , in vivo , in vitro , antimicrobial , minimum inhibitory concentration , antibiotics , pilus , chemistry , biology , bacteria , biochemistry , escherichia coli , genetics , gene

Neisseria meningitidis is known to be highly resistant to lincomycin (minimum inhibitory concentration greater than 32 micrograms/ml). However, during studies on meningococcal piliation, we noticed a significant reduction in the number of pili after cultivation on lincomycin-containing selective media. This observation was followed up by in vitro and in vivo studies on the relation between lincomycin and meningococcal adherence to human epithelial cells. We found a remarkable decrease in in vitro piliation and adherence after exposure to lincomycin at concentrations as low as 0.05 micrograms/ml. By giving four healthy meningococcal carriers lincomycin orally for 3 to 6 days, the possible in vivo effect of lincomycin was studied. A marked decrease in the meningococcal counts of the pharyngeal secretion was observed. One person completely lost his meningococcal strain during the observation period.

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