Open AccessIn vitro activity of teichomycin compared with those of other antibiotics
Author(s) -
H C Neu,
Pornpen Labthavikul
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.24.3.425
Subject(s) - vancomycin , staphylococcus epidermidis , microbiology and biotechnology , gentamicin , staphylococcus aureus , glycopeptide , antibiotics , minimum inhibitory concentration , listeria monocytogenes , in vitro , streptococcus , listeria , bacteria , biology , chemistry , biochemistry , genetics
The glycopeptide antibiotic teichomycin had in vitro activity comparable to that of vancomycin against most gram-positive species, and it inhibited methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis. It was twofold more active against many S. aureus and S. epidermidis isolates than was vancomycin. Teichomycin had activity comparable to that of vancomycin against Listeria monocytogenes and Streptococcus faecalis. It was generally more active against streptococci than was vancomycin. There were no major differences between minimal inhibitory concentrations and minimal bactericidal concentrations of these drugs. Teichomycin acted synergistically with gentamicin against some bacteria.