Intraperitoneal penetration of cefotetan | Zendy

R. Wise | Zendy; I A Donovan | Zendy; J. Drumm | Zendy; J Dent | Zendy; S Bennett | Zendy

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Intraperitoneal penetration of cefotetan

Author(s) -

R. Wise,

I A Donovan,

J. Drumm,

J Dent,

S Bennett

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.2.279

Subject(s) - cefotetan , medicine , anesthesia , surgery , antibiotics , microbiology and biotechnology , biology , antibiotic resistance , imipenem

The intraperitoneal penetration of cefotetan was studied after a 1-g intravenous injection in 25 patients undergoing elective gastrointestinal surgery. Levels of peritoneal fluid were high within 10 min after administration and increased to 44% of the serum levels after 30 min, rising to 115% at 3 h. The mean concentration of cefotetan between 3 and 5 h after administration was 32.3 micrograms/ml. These findings suggest that 1 g of cefotetan administered before abdominal surgery would result in intraperitoneal cefotetan levels necessary to inhibit susceptible pathogens for 5 h or more.

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