Open AccessAntimycoplasmal activity of ofloxacin (DL-8280)
Author(s) -
Yasuaki Osada,
Hidemasa Ogawa
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.23.3.509
Subject(s) - ofloxacin , potency , norfloxacin , lincomycin , erythromycin , microbiology and biotechnology , antibacterial agent , chemistry , antibiotics , pharmacology , medicine , biology , ciprofloxacin , biochemistry , in vitro
Ofloxacin (DL-8280; (+/-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1- pipera-zinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) showed a broader spectrum and a greater potency of antimycoplasmal activity than did pipemidic acid, norfloxacin, tetracyclines, and lincomycin, but was inferior to erythromycin. Its mycoplasmacidal potency against clinical isolates of Mycoplasma pneumoniae was also greater than that of other quinolones and tetracyclines.