Open AccessEffects of Prolonged Cultivation in the Presence of Acyclovir on Recovery of Latent Herpes Simplex Virus from Human Trigeminal Ganglia
Author(s) -
Marcia Lewis,
Kenneth G. Warren,
Verona M. Jeffrey,
D. Lorne Tyrrell
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.23.3.487
Subject(s) - herpes simplex virus , virology , trigeminal ganglion , simplexvirus , aciclovir , in vitro , virus , alphaherpesvirinae , herpesviridae , medicine , biology , viral disease , biochemistry , sensory system , neuroscience
The continuous presence of acyclovir prevented the in vitro reactivation of latent herpes simplex virus from cultures of human trigeminal ganglia derived from 23 randomly selected cadavers. When acyclovir was withdrawn after 30 days, herpes simplex virus was recovered from 3 of 18 cases. Herpes simplex virus was recovered in 9 of 20 (45%) control cases.