Open AccessCeftriaxone pharmacokinetics in newborn infants
Author(s) -
George H. McCracken,
Jane D. Siegel,
Norma Threlkeld,
Marion L. Thomas
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.23.2.341
Subject(s) - ceftriaxone , pharmacokinetics , medicine , plasma concentration , anaerobic bacteria , cephalosporin , anaerobic exercise , antibiotics , anesthesia , physiology , bacteria , microbiology and biotechnology , biology , genetics
Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 micrograms/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.