Open AccessSynergistic Effect of N -Formimidoyl Thienamycin with Gentamicin and Amikacin Against Streptococcus faecalis
Author(s) -
Myles E. Gombert,
Leonard Berkowitz,
Marinella Cummings
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.23.2.245
Subject(s) - thienamycin , amikacin , gentamicin , enterococcus faecalis , chemistry , streptococcus , microbiology and biotechnology , imipenem , antibiotics , bacteria , biochemistry , biology , escherichia coli , antibiotic resistance , genetics , gene
The in vitro activities ofN -formimidoyl thienamycin alone and in combination with amikacin and gentamicin were tested against 10 strains ofStreptococcus faecalis . Synergy was demonstrated in 35% of the combinations tested by the microtiter checkerboard technique; 50% were found to be synergistic with time killing curves.