Cefamandole bile levels in patients with hepatobiliary disease | Zendy

Marwan Uwaydah | Zendy; Hagop M. Kantarjian | Zendy; Maher Osseiran | Zendy; F. Bala | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cefamandole bile levels in patients with hepatobiliary disease

Author(s) -

Marwan Uwaydah,

Hagop M. Kantarjian,

Maher Osseiran,

F. Bala

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.6.1087

Subject(s) - cefamandole , medicine , gastroenterology , cholecystitis , gallbladder , acute cholecystitis , biliary tract , bile duct , common bile duct , liver abscess , antibiotics , surgery , cephalosporin , abscess , biology , microbiology and biotechnology

Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic dose of 1 g administered by intravenous drip showed therapeutically effective concentrations of cefamandole in 84% (11 of 13) of gall bladder samples with a median of 220 micrograms/ml (range, 1.6 to 1,400), and in 100% (13 of 13) of common bile duct samples with a median of 1,100 micrograms/ml (range, 9.0 to greater than 2,000). Only with complete aseptic cystic duct obstruction was cefamandole undetectable in gall bladder bile.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research