Open AccessEffect of Protein Synthesis Inhibition on the Induction of Cell Lysis in Escherichia coli by Mecillinam plus Nocardicin A
Author(s) -
José Berenguer,
Miguel A. de Pedro,
David Vázquez
Publication year - 1982
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.22.6.1070
Subject(s) - mecillinam , lysis , escherichia coli , antibiotics , microbiology and biotechnology , chemistry , escherichia , enterobacteriaceae , biology , cell , biochemistry , gene
Cell lysis can be induced inEscherichia coli by the combined use of the β-lactam antibiotics nocardicin A and mecillinam. Apparently, the induction of cell lysis occurs by a sequential mechanism in which mecillinam acts first, and nocardicin A has a triggering action insensitive to the inhibition of protein synthesis.