Open AccessIn Vitro Evaluation of N -Formimidoyl Thienamycin (MK0787) Combined with Amikacin Against Gram-Negative Bacilli and Staphylococcus aureus
Author(s) -
M. Díez Enciso,
M. L. Mateos Lindemann,
A. Gutièrrez Altès
Publication year - 1982
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.22.6.1064
Subject(s) - thienamycin , amikacin , gentamicin , staphylococcus aureus , microbiology and biotechnology , chemistry , pseudomonas aeruginosa , imipenem , antibiotics , bacteria , biology , antibiotic resistance , genetics
The in vitro synergistic activity ofN -formimidoyl thienamycin and amikacin was determined against gentamicin-resistant enterobacteriaceae,Pseudomonas aeruginosa , andStaphylococcus aureus. N -Formimidoyl thienamycin showed synergism with amikacin against 19 of the gentamicin-resistant strains, 14 of the 49 strains ofS. aureus , and only 1 strain of the 46P. aeruginosa isolates.