High-pressure liquid chromatographic assay of ceftizoxime with an anion-exchange extraction technique | Zendy

C E Fasching | Zendy; Lance R. Peterson | Zendy; K M Bettin | Zendy; Dale N. Gerding | Zendy

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High-pressure liquid chromatographic assay of ceftizoxime with an anion-exchange extraction technique

Author(s) -

C E Fasching,

Lance R. Peterson,

K M Bettin,

Dale N. Gerding

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.2.336

Subject(s) - chromatography , ceftizoxime , chemistry , extraction (chemistry) , high performance liquid chromatography , coefficient of variation , ion exchange , ion chromatography , correlation coefficient , bioassay , ion , biology , mathematics , cefotaxime , biochemistry , statistics , organic chemistry , genetics , antibiotics

An anion-exchange extraction method was used in conjunction with high-pressure liquid chromatography for assay of ceftizoxime in 181 serum samples. Comparison of this method with bioassay gave a linear regression line described by Y = 1.11 + 0.98 X, with a correlation coefficient of 0.984. The anion-exchange extraction method is a fast, reliable method of preparing serum samples containing ceftizoxime for assay by liquid chromatography.

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