Open AccessEffects of moxalactam and cefotaxime on rabbit renal tissue
Author(s) -
Friedrich C. Luft,
George R. Aronoff,
Andrew Evan,
Bret A. Connors,
D. K. Blase,
V. H. Gattone
Publication year - 1982
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.21.5.830
Subject(s) - moxalactam , cefotaxime , cephaloridine , cephalosporin , nephrotoxicity , medicine , pharmacology , chemistry , kidney , endocrinology , antibiotics , biology , microbiology and biotechnology
To determine and compare the effects of moxalactam and cefotaxime on kidneys, we gave these drugs in doses of 750 and 1,500 mg/kg to rabbits for 7 days. Cephaloridine was included as a positive control. Neither moxalactam nor cefotaxime at either dose caused lysosomal enzymuria, changes visible by light microscopy or increased plasma creatine. Both drugs caused minor alterations in glomerular ultrastructure at the higher dose. Cephaloridine, on the other hand, caused widespread renal functional and morphological damage. We conclude that in rabbits, both moxalactam and cefotaxime are remarkably nonnephrotoxic.