Variables in demonstrating methicillin tolerance in Staphylococcus aureus strains | Zendy

Kenji Ishida | Zendy; Phyllis A. Guze | Zendy; G. M. Kalmanson | Zendy; K Albrandt | Zendy; L. B. Guze | Zendy

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Variables in demonstrating methicillin tolerance in Staphylococcus aureus strains

Author(s) -

Kenji Ishida,

Phyllis A. Guze,

G. M. Kalmanson,

K Albrandt,

L. B. Guze

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.21.4.688

Subject(s) - staphylococcus aureus , microbiology and biotechnology , antibiotics , biology , strain (injury) , multidrug tolerance , staphylococcus , bacteria , genetics , biofilm , anatomy

Certain technical considerations which affected the status of methicillin tolerance in Staphylococcus aureus strains were studied. Methods which consistently demonstrated tolerance or intolerance of a given strain were avoidance of inoculum splashing, use of stationary-phase inoculum, 24-h tube incubation, and minimization of antibiotic carry-over. These studies suggested a need for the establishment of a standardized reference for the determination of tolerance.

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