In vivo inhibition of respiratory syncytial virus by ribavirin | Zendy

Jerome F. Hruska | Zendy; Paul E. Morrow | Zendy; Stephen C. Suffin | Zendy; R. Gordon Douglas | Zendy

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In vivo inhibition of respiratory syncytial virus by ribavirin

Author(s) -

Jerome F. Hruska,

Paul E. Morrow,

Stephen C. Suffin,

R. Gordon Douglas

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.21.1.125

Subject(s) - ribavirin , respiratory system , in vivo , virus , paramyxoviridae , virology , lung , drug , medicine , pharmacology , biology , viral disease , hepatitis c virus , microbiology and biotechnology

Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.

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