Open AccessIn vivo inhibition of respiratory syncytial virus by ribavirin
Author(s) -
Jerome F. Hruska,
Paul E. Morrow,
Stephen C. Suffin,
R. Gordon Douglas
Publication year - 1982
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.21.1.125
Subject(s) - ribavirin , respiratory system , in vivo , virus , lung , paramyxoviridae , drug , virology , medicine , turbinates , pharmacology , nose , biology , viral disease , surgery , hepatitis c virus , microbiology and biotechnology
Ribavirin reduced the amount of respiratory syncytial virus in nasal turbinates and lung tissues of experimentally infected cotton rats by over 90%. An effect was seen when the drug was given either intraperitoneally or by aerosol; however, the antiviral effect was achieved at much lower doses when delivered by the aerosol route. No animal deaths due to the drug were seen.