Open AccessComparative in vitro activity of cefmenoxime, cefotaxime, cefuroxime, cefoxitin, and penicillin against Neisseria gonorrhoeae
Author(s) -
Mohammed Y. Khan,
Yunus M. Siddiqui,
Margaret Simpson,
R P Gruninger
Publication year - 1981
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.20.5.681
Subject(s) - cefoxitin , cefotaxime , neisseria gonorrhoeae , cefuroxime , microbiology and biotechnology , penicillin , cephalosporin , antibiotics , beta lactamase , chemistry , biology , bacteria , escherichia coli , staphylococcus aureus , biochemistry , gene , genetics
The in vitro activity of a new beta-lactam antibiotic, cefmenoxime, was compared with those of cefotaxime, cofuroxime, cefoxitin, and penicillin against 72 beta-lactamase-negative and 26 beta-lactamase-positive Neisseria gonorrhoeae. Cefmenoxime was as active as cefotaxime and more active than the other three antimicrobial agents. It inhibited all isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.015 microgram/ml.