Open AccessChemoprophylaxis with cefoxitin and cephalothin in orthopedic surgery: a comparison
Author(s) -
M. Rosenfeld,
Josemberg Marins Campos,
Kenneth R. Ratzan,
I Uredo
Publication year - 1981
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.19.5.826
Subject(s) - cefoxitin , medicine , orthopedic surgery , cephalosporin , chemoprophylaxis , surgery , antibiotics , bolus (digestion) , cefazolin , intravenous bolus , anesthesia , staphylococcus aureus , microbiology and biotechnology , biology , bacteria , genetics
Forty-eight patients who underwent elective hip or knee surgery were randomly divided into two groups. A total of 22 patients received a single 1-g preoperative bolus of cefoxitin, and 26 patients received a single 1-g preoperative dose of cephalothin. At various time intervals, serum and bone samples were taken during the operative procedure. Our data indicated that whereas serum levels of cefoxitin and cephalothin were maintained for at least 2h at levels capable of inhibiting most gram-positive cocci and many gram-negative rods, bone levels of cefoxitin rather rapid decay over a 2-h period. Moreover, in only 58% of the entire cephalothin-treated group were bone levels detectable and then only at a concentration that would inhibited gram-positive cocci. No significant morbidity was observed in either treatment group.