Open AccessInfluence of food on absorption of erythromycin ethyl succinate
Author(s) -
PJ Thompson,
Keith R. Burgess,
G. E. Marlin
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.18.5.829
Subject(s) - erythromycin , bioavailability , absorption (acoustics) , chemistry , plasma concentration , drug , pharmacokinetics , pharmacology , food science , antibiotics , medicine , biochemistry , materials science , composite material
Erythromycin plasma concentrations were determined in 18 subjects after a single dose (800 mg) of a new formulation of erythromycin ethyl succinate taken immediately before, immediately after, and 1 h after food. Adequate absorption occurred with all treatments, although bioavailability was best when the drug was taken before food. Absorption was delayed by food, with the highest and earliest peak plasma erythromycin levels occurring under fasting conditions.