Open AccessComparison of cefotaxime and moxalactam pharmacokinetics and tissue levels
Author(s) -
R. Wise,
Scott Baker,
R. B. Livingston
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.18.3.369
Subject(s) - moxalactam , cefotaxime , pharmacokinetics , urine , latamoxef , cephalosporin , medicine , pharmacology , antibiotics , microbiology and biotechnology , biology
The pharmacokinetics of cefotaxime and moxalactam were compared in six healthy male volunteers aftr the administration of 1-g doses intravenously. Penetration of the compounds into tissue fluid was studied in cantharides-induced blisters. Both serum and tissue fluid levels of moxalactam were higher than those of cefotaxime. The elimination half-life of cefotaxime was 1.2 h, and that of moxalactam was 2.85 h. On the average, 50.5% of cefotaxime and 87.5% of moxalactam were recovered in the urine in 24 h.