Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila | Zendy

D J Pohlod | Zendy; Louis D. Saravolatz | Zendy; Edward Quinn | Zendy; Margaret M. Somerville | Zendy

Open Access

Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila

Author(s) -

D J Pohlod,

Louis D. Saravolatz,

Edward Quinn,

Margaret M. Somerville

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.18.2.353

Subject(s) - clavulanic acid , antimicrobial , legionella pneumophila , microbiology and biotechnology , minimum inhibitory concentration , legionella , chemistry , antibiotics , bacteria , biology , amoxicillin , genetics

A total of 15 Legionella pneumophilia isolated were tested against 16 antimicrobial agents used singly and in combination with clavulanic acid. When combined with clavulanic acid, 4 of the 16 antimicrobial agents produced no enhanced effect. However, the minimal inhibitory concentrations of 12 of the antimicrobial agents were reduced by one-half to one-third when in combination with clavulanic acid. These reductions reflected only a one-dilution decrease, however, in the original minimal inhibitory concentrations. Thus, clavulanic acid combinations appear to be only nominally effective beta-lactamase inhibitors against L. pneumophilia.

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