Susceptibility of Clostridium botulinum to thirteen antimicrobial agents | Zendy

Jana M. Swenson | Zendy; Clyde Thornsberry | Zendy; L M McCroskey | Zendy; C L Hatheway | Zendy; V. R. Dowell | Zendy

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Susceptibility of Clostridium botulinum to thirteen antimicrobial agents

Author(s) -

Jana M. Swenson,

Clyde Thornsberry,

L M McCroskey,

C L Hatheway,

V. R. Dowell

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.18.1.13

Subject(s) - microbiology and biotechnology , nalidixic acid , clostridium botulinum , clindamycin , penicillin , botulism , cefoxitin , agar dilution , gentamicin , clostridium sporogenes , trimethoprim , erythromycin , tetracycline , biology , antimicrobial , antibiotics , minimum inhibitory concentration , clostridium , staphylococcus aureus , bacteria , toxin , genetics

A total of 224 strains of Clostridium botulinum (including isolates from 14 patients with infant botulism and 4 with wound botulism) and 15 strains of C. sporogenes were tested by agar dilution for susceptibility to tetracycline, metronidazole, erythromycin, penicillin, rifampin, chloramphenicol, clindamycin, cephalothin, cefoxitin, vancomycin, sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. At least 90% of the C. botulinum strains tested (except for nonproteolytic strains of toxin type F with penicillin) were susceptible to all drugs except sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. Minimal inhibitory concentrations for strains from patients with infant and wound botulism were similar to those for other C. botulinum strains.

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