Open AccessSusceptibility of Clostridium botulinum to thirteen antimicrobial agents
Author(s) -
Jana M. Swenson,
Clyde Thornsberry,
L M McCroskey,
Charles L. Hatheway,
V. R. Dowell
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.18.1.13
Subject(s) - microbiology and biotechnology , nalidixic acid , clostridium botulinum , clindamycin , penicillin , botulism , cefoxitin , agar dilution , gentamicin , clostridium sporogenes , trimethoprim , erythromycin , tetracycline , biology , antimicrobial , antibiotics , minimum inhibitory concentration , clostridium , staphylococcus aureus , bacteria , toxin , genetics
A total of 224 strains of Clostridium botulinum (including isolates from 14 patients with infant botulism and 4 with wound botulism) and 15 strains of C. sporogenes were tested by agar dilution for susceptibility to tetracycline, metronidazole, erythromycin, penicillin, rifampin, chloramphenicol, clindamycin, cephalothin, cefoxitin, vancomycin, sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. At least 90% of the C. botulinum strains tested (except for nonproteolytic strains of toxin type F with penicillin) were susceptible to all drugs except sulfamethoxazole-trimethoprim, nalidixic acid, and gentamicin. Minimal inhibitory concentrations for strains from patients with infant and wound botulism were similar to those for other C. botulinum strains.